You’ve probably heard about Profhilo or Rejuran. They’re being dubbed the ‘injectable moisturisers‘ of the future — skin boosters that don’t just sit on the surface but work from within. These injectable treatments represent a major leap in the arena of biostimulators and anti-ageing collagen boosting treatments.
These two bio-remodelling injectable treatments are popular choices for good reason. They’re not just cosmetic — they’re medical procedures that support skin regeneration, collagen formation, and long-term skin health.
For those with aging-related skin concerns, acne scar treatment needs, or who simply want firmer skin and smoother texture, both Rejuran and Profhilo deliver — with different strengths.
The Future of Skincare
A revolutionary tissue bioremodeller. Cutting-edge technology delivering natural results. This revolutionary treatment is great for combating the ageing process as it stimulates the production of collagen and elastin, resulting in increased elasticity and support.
What Is Rejuran?
Rejuran (often referred to as Rejuran Healer) is a regenerative injectable derived from salmon DNA extract — specifically polynucleotides that promote cellular repair and skin regeneration. This family of polynucleotides includes DNA fragments that help heal damaged skin, stimulate collagen production, and restore skin barrier function.
Rejuran is widely used for treating acne-scarred skin, aging-related skin concerns, and environmental damage. Think of it as your skin’s internal repair agent — a bio-remodelling agent that heals from the cellular level outwards.

Request a consultation
To receive a free private consultation, simply fill out the online enquiry form. Let us know what procedure(s) you are considering and we will get back to you with a time and day to suit.
Key Benefits
Why Choose Rejuran?
Here’s why Rejuran is one of the most popular options at aesthetic clinics:
- Boosts collagen production and elastin stimulation
- Improves skin texture, hydration levels, and skin tone
- Enhances skin elasticity and thickness in deeper layers
- Reduces enlarged pores, acne scars, and atrophic scars
- Supports skin healing, especially post-laser or microneedling
- Calms inflammation with its anti-inflammatory properties
- Improves the appearance of dark circles and uneven skin tone
Clients dealing with collagen depletion, loose skin, or visible signs of
sun damage are excellent candidates for Rejuran treatments.
Treatment Protocol
Rejuran Protocol
The Rejuran protocol is precise and tailored for maximal collagen remodelling:
- Initial Sessions: 3–4 treatments spaced at 2–4 week intervals
- Maintenance Sessions: Every 4–6 months
- Injection Technique: Manual injections or an injector gun using micro-injections across the face
- Injection Sites: Full face, under-eyes, neck, décolletage, and hands
- Downtime: Mild swelling, slight redness for 12–36 hours
You may experience mosquito-bite-like bumps for the first 6–24 hours after injections.
Aesthetic practitioners often use numbing cream to minimise discomfort during the treatment session.
What Is Profhilo?
Profhilo is a non-surgical cosmetic treatment that is different from traditional
volumising procedures. It is placed in specific points just under the surface of the skin
using a fine delivery technique. Rather than adding volume, the treatment is designed
to improve overall skin quality and hydration.
As with all cosmetic procedures, individual experiences can vary. Some people may notice
visible changes in their skin’s appearance, while others may find the effect more subtle.
The treatment plan, expected outcomes, and suitability are best discussed during a
one-on-one consultation with a qualified health professional.
Key Benefits
Benefits of Profhilo
Profhilo targets multiple aspects of skin health at once:
- Increases tissue hydration and collagen stimulation
- Firms and tightens loose skin in the lower face and neck
- Restores skin firmness, elasticity, and radiant glow
- Enhances skin thickness and reduces the appearance of wrinkles
- Offers anti-inflammatory effects, antioxidant effects, and gradual improvements in hydration levels
It’s a favourite among clients chasing the glass skin, plump look — with no filler distortion.
Treatment Protocol
Profhilo Protocol
This is where Profhilo stands out:
- Initial Injections: Two sessions spaced 4 weeks apart
- Maintenance Treatments: Every 6–12 months
- Injection Technique: 5 bio-aesthetic injection points per side using manual injections
- Downtime: Minimal. Small lumps can form at injection sites but resolve within 2–10 hours
Profhilo is suitable for clients wanting a medical procedure that delivers
visible, subtle improvements in skin hydration and skin quality
improvements without changing their natural look.
Where Can They Be Used?
Treatment Areas
Rejuran injections can be used across a variety of areas:
- Full face
- Under-eyes (dark circles)
- Neck and décolletage
- Back of hands
- Areas with depressed acne scars or enlarged pores
Profhilo injections are typically used on:
- Mid and lower face
- Neck
- Décolletage
Due to its fluid spread, Profhilo is not suited to under-eye or highly mobile areas.
Main Differences
Feature | Rejuran Healer | Profhilo |
---|---|---|
Key Ingredient | Polynucleotides (salmon sperm DNA extract) | Blend of high & low molecular weight HA |
Primary Effects | Skin repair, collagen synthesis, and skin healing | Deep hydration, collagen formation, and skin glow |
Injection Technique | Micro-injections or injector gun | BAP (Bio Aesthetic Points) manual injection |
Sessions Required | 2–4 Rejuran sessions | 1–2 sessions |
Best For | Damaged, sensitive, acne-prone, aging skin | Dry skin, dull skin, skin laxity, aging |
Downtime | Mild swelling, slight redness (12–36 hrs) | Minimal downtime (2–10 hrs) |
Treatment Plan | Every 3–6 months | Every 6–12 months |
They’re both injectable moisturisers — but think of Rejuran as the repair serum,
and Profhilo as the hydrating plumper.
Which One Is Right for You?
Expert Guidance
Here’s my honest take after treating hundreds of clients with both:
Choose Rejuran if:
- You have acne scars, sensitivity, or post-inflammatory pigmentation
- Your skin feels thin, damaged, or reactive
- You want gentle regeneration and healing
Choose Profhilo if:
- You’re noticing fine lines, sagging, or dullness
- You want to restore bounce and hydration
- You’re after a dewy, refreshed look without filler volume
Still unsure? I often combine both — Profhilo for deep hydration and structure,
and Rejuran for barrier repair and texture smoothing.
Yes, they can play nicely together (with the right treatment spacing).
How Long Do the Results Last?
Results & Longevity
Rejuran results are subtle but cumulative — think of it as a
long-term investment in your skin health. You’ll notice
smoother texture and calmness within weeks, but
optimal results appear after 3+ sessions.
Profhilo gives faster gratification — many clients see
glow and plumpness within days of their second treatment.
Results typically last 6 months, though some report
benefits beyond that with maintenance.
Side Effects & Safety
Both are considered very safe when administered correctly, but here’s what to expect:
Rejuran Side Effects:
- Pinprick swelling for 1–2 days
- Possible redness or bruising
- Rare allergic response (especially if seafood-sensitive — always mention this)
Profhilo Side Effects:
- Temporary lumps at injection sites (settle quickly)
- Mild redness or swelling
- Bruising (as with any injectable)
Pro Tip: No actives (like retinol or AHAs) for at least 3–5 days post-treatment.
Let your skin chill and repair.
Frequently Asked Questions
Can I combine Rejuran and Profhilo in one treatment plan?
How soon can I see results from Rejuran or Profhilo?
Are there any long-term risks with Rejuran or Profhilo?
Which treatment is better for acne scars?
Can I return to work or daily activities after treatment?
Request a consultation
To receive a free private consultation, simply fill out the online enquiry form. Let us know what procedure(s) you are considering and we will get back to you with a time and day to suit.